Tuesday, 9 October 2018

BioLargo Spotlight: NSERC Grant Awarded to Evaluate AOS Water Chemistry


If you follow BioLargo Water and its Advanced Oxidation System, you may sometimes wonder how exactly it functions – ie how does it actually treat water? You have probably seen our short descriptions of its function: that it generates highly reactive iodine molecules at its electrodes, resulting in disinfection and decontamination, but the truth is A) this is an oversimplification and B) you may not be entirely clear on what this means!

To expand on this simplified explanation: in the AOS there are two modes of actions by which it treats water. One is the oxidation – the chemical action of removing electrons - of proteins inside bacteria passing through the AOS, resulting in inactivation or killing of those bacteria. The second mode of action is the breaking down of pollutants by oxidation, that is to say the structural or chemical alteration of chemical pollutants by the process of oxidation.

A peak at an AOS Spiral Reactor
Understanding these modes of action is crucial to BioLargo from a technical AND business perspective. Why? Because by having a solid understanding of how the AOS works on a fundamental molecular level, we can optimize and modify the AOS to maximize its water treatment potential without causing it to consume more electricity or consumables – both of which translate to money ($$$)!

We’re happy to say that BioLargo Water, our water treatment subsidiary, has been awarded $50,000 CAD last week by the National Science and Engineering Research Council of Canada (NSERC) to investigate, using cutting-edge analytical tools, the mechanism of complete breakdown of harmful compounds by the AOS (discussed further in this article). Congratulations to BioLargo Water!

Wastewaters can be treated by a huge variety of techniques. In recent years, electrochemical treatment has become of high interest to the water treatment industry given its ability to provide simultaneous disinfection and oxidation/reduction of chemical compounds – this is why we invented the AOS. Electrochemical treatment has shown disinfection capabilities for a variety of waters and good performance for both disinfection and decontamination. The advantages of the AOS include its ability to treat wastewaters cost- and energy-efficiently, at ambient temperature and pressure, its requirement for minimal chemical addition, and its low solid waste production. However, any advanced oxidation technique has the potential to generate by-products (BPs) while breaking down harmful organics. It is of high importance, therefore, to evaluate the AOS for the possible generation of of by-products (BPs) – it’s essentially a necessary step for an electrochemical water treatment system.

Dr. Susana Kimura-Hara
Because our AOS reactor has reduction chambers which would potentially eliminate/minimize the production of iodinated-BPs (I-BP), BioLargo Water proactively decided to peruse two scientific studies to prove that the AOS effluent is 100% safe. The first study is a toxicity study on zebra fish which we discussed in a previous blog. The second study pertains to the identification and quantification of any potential I-BPs made by the AOS. These two studies complement each other and are designed to eliminate any market risk in the future. BioLargo Water, our water treatment subsidiary, has been awarded $50,000 CAD last week by the Canadian Government to investigate the water quality of the AOS’s effluent. This grant was awarded after BioLargo Water showed through the hard work of their team that the AOS reactor can be used for treatment of several municipal and industrial wastewaters and allow effective and efficient water reuse. The recycling of water allowed by our system presents a great value proposition for industry’s current and future water needs.

Dr. Susana Kimura-Hara at the University of Calgary is our lead academic partner in this project. She will use her unique expertise in analytical chemistry, specifically in the field of identification and formation mechanisms of unregulated disinfection by-products, and will be using state-of-the-art techniques and instrumentations that are not otherwise available to BioLargo Water. This project will empower BioLargo Water to accelerate the commercialization of the AOS technology with assurances of the safety of its effluent.

Wednesday, 3 October 2018

Analyst Report on BioLargo, Inc. Published by The Edison Group


Our first analyst coverage has been initiated by The Edison Group and the first report is now published internationally through their distribution channels. The first report can be found at this link:  https://www.edisoninvestmentresearch.com/research/report/biolargo/preview/. It can also be found at the Investor Relations section of our web site HERE.






We selected and engaged The Edison Group to provide coverage for at least one year. This work will be instrumental in helping us share our story as we grow our business. We selected The Edison Group because they are known for their integrity, credibility and trustworthiness in producing high quality research reports that strive to be objective, insightful, financially rigorous, readable and timely. See their stated principals here: https://www.edisoninvestmentresearch.com/about/principles

Edison is an investment research and advisory company, with offices in North America, Europe, the Middle East and AsiaPac. The heart of Edison is their world renowned equity research platform and deep multi-sector expertise. At Edison Investment Research, their research is widely read by international investors, advisors and stakeholders. They follow more than 700 stocks, reach 128 countries, have 420 corporate clients and do all this with a team of 110 employees.

Tuesday, 2 October 2018

BioLargo acquires breakthrough stem cell therapy technology to expand medical product portfolio

 Westminster, CA – October 2, 2018 – BioLargo, Inc. (OTCQB:BLGO), developer of sustainable science and technologies and a full-service environmental engineering company, announced today that it had entered into definitive agreements to acquire a breakthrough stem cell therapy technology called “SkinDisc”. Developed by Scion Solutions, LLC, SkinDisc uses a patient’s own bone marrow and plasma to generate a cell-rich biogel which heals chronic wounds. The product has been tested in over 250 patient cases with no adverse side effects, and successfully aided in the salvage of limbs that otherwise would have been amputated.

The SkinDisc product will be sold through BioLargo subsidiary Clyra Medical Technologies, Inc. In addition to the SkinDisc product, Scion’s key team members will join Clyra to support Clyra’s commercial strategy, including Dr. Brock Liden, a renowned medical podiatrist and expert in wound care and diabetic limb salvage, and Spencer Brown, a medical device industry veteran with more than 35 years of experience working in medical sales, account management, and distribution in the medical device industry.

The acquisition is contingent upon Clyra raising initial minimum capital of $1 million. If Clyra is unable to raise the funds in 120 days, either party may unwind the transaction.  

As consideration for the SkinDisc product and other intellectual property, Scion will receive approximately 20% of Clyra’s common stock (half of which would be released upon raising the $1 million initial minimum capital, and the second half released subject to performance metrics), 7,142,858 shares of BioLargo common stock (subject to the same escrow and earn out provisions), and a promissory note in the principal amount of $1,250,000 which would be paid through the capital raise conducted by Clyra.

Dennis P. Calvert, CEO of BioLargo commented, “Company management believes this transaction carries significant value for both BioLargo and Clyra for several reasons. First, our antimicrobial products and the SkinDisc are highly complementary as they will both serve the same advanced wound care market and can often be used together. Second, a fairness opinion report written by an independent evaluator suggested that there is good evidence, based on comparable company analysis, that the combined value of Clyra and Scion would be approximately $33 million following this transaction.  Third, the two technical platforms - our antimicrobial products and the SkinDisc - present a long list of product design opportunities establishing a foundation upon which to build an internationally competitive wound care company. Finally, we are particularly excited to be working with the Scion team members that have successfully launched a number of products into the medical industry and believe they bring crucial expertise regarding how to position these products and support the selling process. We remind our shareholders that we cannot predict the timing of the approval of our current application before the FDA, but that we are highly encouraged with the interaction with the FDA staff and believe we are on the right track to be successful.”

Clyra Medical Technologies develops products for wound management that feature broad-spectrum antimicrobial efficacy with no known acquired resistance, sustained release, biofilm efficacy, and being gentle on skin and tissue. Its first product called the Clyra Wound Wash is currently in review by the FDA under a 510 (k) application. The company believes its first target commercial markets will be in the areas of general wound therapy, infection control for the orthopedic surgery market, and a dental rinse. The Clyra technology presents the potential for multiple additional product designs.

About BioLargo, Inc.
BioLargo, Inc. is an innovative technology developer and environmental engineering company driven by a mission to "make life better" by delivering robust, sustainable solutions for a broad range of industries and applications, with a focus on clean water, clean air, and advanced wound care. We develop and commercialize disruptive technologies by providing the capital, support, and expertise to expedite them from "cradle" to "maturity" (www.biolargo.com). Our engineering division features experienced professional engineers dedicated to integrity, reliability, and environmental stewardship (www.biolargoengineering.com). Our industrial odor control division, Odor-No-More (www.odornomore.com) features CupriDyne Clean Industrial Odor Eliminator (www.cupridyne.com), which eliminates the odor-causing compounds and VOCs rather than masking them, and is now winning over leading companies in the solid waste handling and wastewater industries and other industries that contend with malodors and VOCs. Our subsidiary BioLargo Water (www.biolargowater.ca) develops the Advanced Oxidation System "AOS", a disruptive industrial water treatment technology designed to eliminate waterborne pathogens and recalcitrant contaminants with better energy-efficiency and lower operational costs than incumbent technologies. Our subsidiary Clyra Medical (www.clyramedical.com) features effective and gentle solutions for chronic infected wounds to promote infection control and regenerative tissue therapy.

Contact Information Dennis Calvert President and CEO BioLargo, Inc. 949-643-9540 x2

Friday, 28 September 2018

BioLargo Spotlight: AOS Mobile Lab


Yesterday we had the great, long-awaited pleasure of receiving our AOS Mobile Lab at the Northern Alberta Institute of Technology (NAIT). What’s a Mobile Lab? It’s a fully weatherized modified shipping container that will contain our AOS and its treatment train for use in field demonstration pilots. It’s a big step for the AOS and for BioLargo.

We’re hard at work assembling the equipment in the lab now
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Truck unloading the mobile lab
Outside of the weatherized lab
Time to move the equipment in here...
Rendering of equipment being prepared for Mobile Lab

Tuesday, 25 September 2018

BioLargo CEO Dennis Calvert Reports Breakthrough Commercial Success

Today our President and CEO Dennis Calvert appeared on Uptick Newswire's Stock Day Podcast with Everett Jolly to talk about some highlights of our company's important successes in the past months.

You can listen to the interview right here!




  • BioLargo’s odor and VOC control division is company’s first big commercial success
    • On current run rate, sales are predicted to top $1M for 2018
    • Our flagship product, CupriDyne® Clean, recently secured a fourth national waste handling industry account, and is processing its fifth national account now
    • The company is hiring more staff to continue expanding the product’s regional adoption for national accounts – two of the company’s national accounts awarded 100% adoption of CupriDyne Clean in Southern California (Orange County + Los Angeles)
    • Total addressable market (TAM) for odor control product is estimated at $1.31B USD*.
      • Landfills: $228M
      • Composting: $118M
      • Transfer stations: $365M
      • WWT Plants: $720M
      • *(Based on the assumption, which the company has previously reported that its smaller target locations should average approximately $4,000 in potential revenues per month, and larger locations account for $10,000 in potential revenues per month.)
    • Our current national accounts have 1,929 locations
    • We have expanded from only selling odor control products to offering a complete odor control solution, including: full-service engineering, design, construction and installation of delivery systems, and monthly maintenance and services for landfills, waste transfer stations, recycling centers and wastewater treatment plants
  • An update on Clyra Medical’s FDA 510(k) application in process
    • Recall that our first application from late last year was re-directed into the office of combination products – we decided that given the various demands that would be required under that route, and in light of our financial resources for Clyra, our best move was to re-apply with the FDA under 510 (k) with a new product. The first product it is on hold until we can revisit the product strategy later with more resources
    • The Company filed a new 510 (k) application in June of 2018
    • We have received questions and comments about our application from the FDA and are processing those now
    • While the timing and outcomes are unpredictable given the nature of the process, we are not deterred and intend to push through the arduous process until successful
    • We want to remind our stockholders that as a platform technology company we have a long menu of product designs to choose from and pursue as resources permit and we have experts in this area working with the company
  • Our plan to up-list the company’s stock to Nasdaq
    • OTC is an increasingly difficult place for a company’s  stock to be traded. The pool of investors is limited, and many investors are prohibited from investing in stocks on the OTC.
    • Investors face increased barriers with brokerage firms who don’t want to handle shares of OTC companies because of the increased paperwork and lower profit margin on those accounts
    • Price volatility is often higher on OTC
    • Outgrown the OTC
    • In order to qualify for an up-list on the Nasdaq capital market exchange, we will need to pass a qualitative review, and meet 2 primary quantitative measures- achieve a net shareholder equity of $5 million and a $4.00 stock price.  We believe that we will also require a fully underwritten offering simultaneous with an uplist
  • Brief update on the company’s progress on its pre-commercial pilots for its advanced water treatment technology, the Advanced Oxidation System (AOS). BioLargo’s engineering team is building units for these pilots
    • Efficacy of the AOS is proven – its low energy low cost claims are validated at small scale
    • 2 pre-commercial pilots are in process
In closing, Dennis reminded the audience that BioLargo will become known as a great American success story that will always honor its Canadian innovators and encouraged everyone to join us in our important journey to “make life better” as we build BioLargo into a great company.

Thursday, 20 September 2018

BioLargo Spotlight: Pharmaceuticals in Water


Diseases are treated and cured with man-made chemicals every day – it’s a fact of life. However, scientists and public officials have long be concerned with the question: what happens when those chemicals (pharmaceuticals) come in contact with a healthy person? As is often the case in science, the answer is: well …. It depends!

When a human or animal consumes pharmaceutical products (PPs), what happens to them? These substances are excreted, disposed from the households through sewers and released into the aquatic environment. PPs are an important group of potential endocrine-disrupting compounds (EDCs) which have recently attracted much attention of the international scientific community. PPs such as analgesics, antibiotics, antiseptics, hormones and antidepressants were detected in influents of wastewaters treatment plants, in surface water, in ground water and even in drinking water resources across the world. Their occurrence and persistence in the aquatic ecosystems can lead to an adverse impact on human life and aquatic systems. Research has shown that PPs may mimic or alter endocrine system pathways, potentially leading to forms of gene alteration (Boberg et al., 2010; Verlicchi et al., 2012). Once in the environment, pharmaceutically active PPs can produce a wide variety of subtle effects on aquatic and terrestrial organisms. Thus, it is crucial to develop efficient and cost-effective treatment technologies for removal of such compounds from water.

Pharmaceutical products (PPs) are a large and diverse group of compounds designed to prevent, cure and treat disease and to improve health. The prevalence of their usage is increasing constantly due to numerous factors such as the discovery of new diseases, the expanding population, the inverting age structure in the general population, and expiration of patents and the consequent availability of less expensive generics. The annual production volume of drugs has been estimated to be several hundreds of tons. (Martinez et al., 2011; Halling Sorensen et al., 2011).

Examples of pathways for pharmaceuticals to enter the environment





Trace concentrations of human and veterinary pharmaceutical compounds and metabolites have been detected in surface water, groundwater, and drinking water even after going through water treatment including conventional physical and biological treatment processes. Wastewater treatment plants are not yet efficient in removing these micropollutants (PPs) from wastewaters so they are released to the environment. Several pharmaceutical products cannot be oxidized even during conventional biological treatments. Other treatment technologies such as membrane processes are being increasingly implemented in water treatment because these technologies combine process stability with an excellent effluent quality. However, factors such as the cost of treatment, the tendency for membranes to foul, and for pollutants to accumulate in the reject stream are major issues for this technology.

Currently, efforts are directed toward environmentally friendly, less expensive, relatively simple and efficient technologies that can oxidize persistent organic pollutants. BioLargo’s Advanced Oxidation System (AOS) has been successfully demonstrated for oxidation of emergent organic contaminants such as PPs. The preliminary investigation conducted by the research team of Centre Des Technologies De L’Eau (CTE) using the AOS was very promising. The AOS has proved to be an efficient treatment tool for municipal wastewater (MWW) loaded with pharmaceutical pollutants such as Carbamazepine (CBZ), Ibuprofen (Ibu) and Amoxicillin (Amox). The contribution of the AOS to remove PPs from MWW exceeded 95%. Funded by the Canadian ARD NSERC grant, BioLargo and CTE researchers are optimizing the AOS technology for an efficient treatment of MWW loaded with PPs. This project aims to establish the economic and environmental interest of the AOS process for the treatment of persistent organic compounds such as PPs. 


References:


Tuesday, 18 September 2018

BioLargo Spotlight: BioLargo's Newly Redesigned Website!


Today we launched BioLargo’s updated website! Replacing the company’s original (and sorely outdated) website, the new page uses modern web design tools and assets, making it a huge aesthetic and functional upgrade. You can find the website at the same URL – www.biolargo.com. We encourage our followers and shareholders to explore the new site and see the improvements for themselves.














We are very excited about the new site, as it represents a big improvement to the company’s digital presence. BioLargo is a fast-moving and dynamic company with many high growth potential assets and business units, and its online presence must be of a standard befitting our exciting and important portfolio. We think this new website represents a significant step toward that goal.

You can comment on our new website on Twitter at @BioLargo – we’d love to hear from you!


What is a BioLargo Spotlight?

It’s an exciting time at BioLargo. We’re moving fast, and it can be difficult to keep our stockholders and the investing public informed of our progress. In light of this, we will be posting a series of short articles titled “BioLargo Spotlight”, highlighting certain business activities and other important information in between our required SEC filings. Of course, these do not replace our public filings, which contain more complete information than can be delivered in this forum, and thus we urge you to carefully read and rely on those filings for definitive information, and to review our risk factors and caution regarding forward-looking statements. We are optimistic about our business as we work hard to continue to grow and ultimately generate profits for our stockholders.  

Legal Disclaimer

Our attorneys remind us that while we believe these developments are important and that these small victories could add up and lead to big victories, at this stage they do not rise to the level of an official material disclosure. As the size and magnitude of these developments become material, we will naturally report that information in an 8-K and our regular SEC filings.



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